Fattah H. Fattah, Azad Star Hattam, Zana Omar kak Abdullah, Khanda A. Anwar, Rezhen J. Rashid, Abdullah K. Ghafour, Alaa B. Latif, Hiwa O. Abdullah and 2 more
Introduction Isolated brain hydatid disease (BHD) is an extremely rare form of echinococcosis. A prompt and timely diagnosis is a crucial step in disease management. This study is a systematic review of studies on intra-parenchymal BHD. Methods Studies that had the following properties were included: 1) The…
Hydatid Disease of The Brain Parenchyma: A Systematic Review
Fattah H. Fattah, Azad Star Hattam, Zana Omar kak Abdullah, Khanda A. Anwar, Rezhen J. Rashid, Abdullah K. Ghafour, Alaa B. Latif, Hiwa O. Abdullah and 2 more
IntroductionIsolated brain hydatid disease (BHD) is an extremely rare form of echinococcosis. A prompt and timely diagnosis is a crucial step in disease management. This study is a systematic review of studies on intra-parenchymal BHD.
MethodsStudies that had the following properties were included: 1) The intra-parenchymal brain infection had been confirmed by diagnostic modalities, surgical findings, or histopathology. 2) The patient details were provided in the study. 3) The cystic lesion [s] were located intracranially.
ResultsAltogether, 112 studies with a sample size of 178 cases met the inclusion criteria. Males (60.1%) showed a higher prevalence of the disease than females (38.2%). Most of the cases (64%) were affected during the first and second decades of their lives. Left-side multi-lobe involvement was the most common type of involvement (28.1%), followed by right-side multi-lobe involvement (26.4%). Surgery was the primary treatment option (97.2%), with the Dowling technique or the modified Arana-Iniguez method as the preferred approach. The total recurrence and mortality rates were 7.3% and 3.4%, respectively.
ConclusionThe definitive treatment for BHD is surgery, with the aim of removing cysts intact or excising mass lesions completely. A history of cyst rupture during operation may increase the likelihood of recurrence, and an extensive follow-up is required.
Rawezh Salih, Berun A. Abdalla, Ayman M. Mustafa, Khanda A. Anwar, Abdullah Dler Ahmad, Wafa A. Hamadameen, Hidayat Anwar yaseen, Hawnaz S. Abdullah and 7 more
Introduction Infections of sterile body fluids are significant contributors to mortality and morbidity. Accurate species-level identification and understanding of the antimicrobial resistance profiles are crucial for selecting appropriate antimicrobials for empirical and targeted therapy. This study aims to examine…
Changing Face of Antimicrobial Resistance: A Cross-Sectional Study
Rawezh Salih, Berun A. Abdalla, Ayman M. Mustafa, Khanda A. Anwar, Abdullah Dler Ahmad, Wafa A. Hamadameen, Hidayat Anwar yaseen, Hawnaz S. Abdullah and 7 more
IntroductionInfections of sterile body fluids are significant contributors to mortality and morbidity. Accurate species-level identification and understanding of the antimicrobial resistance profiles are crucial for selecting appropriate antimicrobials for empirical and targeted therapy. This study aims to examine the distribution of various bacterial species and their evolved antimicrobial resistance profiles isolated from different body fluids.
MethodsThis retrospective study evaluated 301 body fluid samples collected at a tertiary hospital between January 2023 and December 2023. Samples were gram-stained and cultured on an appropriate media. Bacterial identification and susceptibility testing were performed using the BD Phoenix™ system, with disk diffusion method used for antibiotics not available in the system.
ResultsMicrobial growth was detected in 151 cases (50.2%), with a comparable prevalence among males and females (53.0% vs. 46.7%). The mean age was 49.81± 24.1 years. Growth rates were slightly higher in hospital-acquired infections (55.7%) than in community-acquired infections (49.2%). Cerebrospinal fluid showed the highest growth rate at 34.3%. Among the isolates, Streptococcus species were the most common (14.6%), while Escherichia coli was the predominant Gram-negative bacterium (13.2%). Sensitivity was highest with tigecycline (100%) and meropenem (92%), whereas resistance was most notable against ampicillin-sulbactam (100%) and azithromycin (95.2%). Multidrug resistance was identified in 106 isolates (70.2%).
ConclusionHigh antibiotic resistance and multidrug-resistant strains underscore the need for rigorous antibiotic stewardship and improved infection control to address untreatable infections.
