The Role of G1/S Phase Cyclins in Colorectal Cancer: A Review Hawbash M. Rahim, Omer Ates, Fahmi H. Kakamad, Marwan N. Hassan, Berun A. Abdalla, Hiwa O. Abdullah, Shvan H. Mohammed, Rawezh Q. Salih and 1 more Colorectal cancer is a highly prevalent cancer with a high mortality rate. Although the colorectal carcinogenesis mechanism is not fully understood yet, it has been proven that most cancers result from the accumulation of genetic mutations, mostly in the genes responsible for cell cycle regulation, leading to… 2023 752 reads 0 citations doi:10.58742/bmj.v1i2.31 Full text PDF XML Read abstract — read the abstract for The Role of G1/S Phase Cyclins in Colorectal Cancer: A Review Review Articles The Role of G1/S Phase Cyclins in Colorectal Cancer: A Review Hawbash M. Rahim, Omer Ates, Fahmi H. Kakamad, Marwan N. Hassan, Berun A. Abdalla, Hiwa O. Abdullah, Shvan H. Mohammed, Rawezh Q. Salih and 1 more Colorectal cancer is a highly prevalent cancer with a high mortality rate. Although the colorectal carcinogenesis mechanism is not fully understood yet, it has been proven that most cancers result from the accumulation of genetic mutations, mostly in the genes responsible for cell cycle regulation, leading to uncontrolled and excessive cell growth. Hence, cyclins may have a significant role in cancer development and progression. Although many studies have been carried out on the expression of these cyclin proteins to indicate their role in colorectal cancer development and their correlation with patient outcome, the currently available data is quite controversial; thus, no certain conclusions can be made. This review article summarizes current knowledge regarding the role of G1/S cyclins, such as cyclin D, E, and A, in colorectal cancer and discusses their potential as prognostic biomarkers and therapeutic targets. Hence, it may provide the groundwork for future research. Keywords Colorectal cancer · Cyclin E · Cyclin D · Cyclin A · Cell cycle regulation All subjects Barw Medical Journal. 2023;1(2) Read the article PDF XML
