Barw Barw Medical Journal 2960-1959 2024 03 07 Presentation and Management of Porocarcinoma: A Systematic Review with Meta-Analysis of More Than One Thousand Patients 10.58742/7xjek960 eng Aland S. Abdullah College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. alandsalihh10@gmail.com Suhaib H. Kakamad Department of Immunology and Hematology, College of Medicine, Kurdistan University of Medical Science, Sanandaj, Iran. suhaib.kakamad@gmail.com Fakher Abdullah Kscien Organization for Scientific Research (Middle east Office), Azadi Mall, Hamid Street, Sulaymaniyah, Iraq. fakherabdullah1976@gmail.com Yousif M. Mahmood Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. yousuf.smarthealth@gmail.com Gona M. Fatah Department of Biology, College of Education, University of Sulaimani, Sulaymaniyah, Kurdistan, Iraq. gona.fatah@gmail.com Imad J. Habibullah Bakhshin Medical Community Halabja, Halabja, Sulaymaniyah, Kurdistan, Iraq. Imad.Habibullah@gmail.com Ronak S. Ahmed Department of Dermatology, Teaching Center for Treating Skin Diseases, Sulaimani Directorate of Health, Sulaymaniyah, Kurdistan, Iraq. ronakahmed76@gmail.com Rebaz H. Ali Hiwa Cancer Hospital Centre, Sulaimani Directorate of Health, Sulaymaniyah, Kurdistan, Iraq. rebaz.ali12@gmail.com Ari M. Abdullah Department of Pathology, Sulaimani Surgical Teaching Hospital, Sulaymaniyah, Kurdistan, Iraq . ariabdullah1978@gmail.com Hiwa O. Abdullah Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. hiewaom96@gmail.com Berun A. Abdalla Department of Biology, College of Education, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. berun.anwer95@gmail.com Rawezh Q. Salih Department of Biology, College of Science, University of Sulaimani, Sulaymaniyah, Kurdistan, Iraq. rawezh.salih@gmail.com Abdulwahid M. Salih College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. Abdulwahid.Salih@gmail.com 2024 01 25 Introduction Porocarcinoma is an aggressive cutaneous carcinoma arising from the intraepidermal component of the sweat glands. Given its uncommon nature, only a limited number of studies have addressed this issue. This study summarizes the different presentations and management of the disease. Methods The eligible databases were searched to identify English-language studies published up to January 16th, 2024. The inclusion criteria comprised studies that focused on the presentation and management of eccrine porocarcinoma, with a clear statement of the outcomes of the chosen management. The data collected from the studies included the first author's name, country of study, type of study design, patient demography, the clinical presentation of the tumor and its location, histopathological findings, metastasis status, treatment strategy, and the subsequent prognosis. Results The initial search yielded 817 papers, with only 22 meeting the inclusion criteria. The studies comprised 1004 patients with a mean age of 78.7 years. In total, 527 (52.5%) of them were male and 461(45.9%) were female. The most commonly affected regions were the head and neck followed by the lower extremities. The most frequent treatment option was surgical excision in 876 (87.3%) patients. Distant metastasis accounted for about 2%, while lymph node involvement, occurred in 36 cases (3.6%). A good prognosis was reported in 57.3% of the cases. Both the age and tumor size had a significant effect on prognosis (p <0.05). Conclusion The lesion can develop anywhere on the body, with a survival rate exceeding 50%. Wide-based surgical excision remains the predominant treatment option.