Barw Barw Medical Journal 2960-1959 2023 11 15 Presentation and Management of Intermammary Epidermoid Cyst: A Case Series 10.58742/z1spkr36 eng Mohamed L. Elsaie Department of Dermatology, National Research Centre, Cairo, Egypt. mohamed.elsaie@gmail.com Wael Zekri Department of Pediatric Oncology, National Cancer Institute, Cairo University, Fom El-khalig, Square Kasr El-Aini St., Cairo, Egypt. wael.zekri@gmail.com Marwa Said Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt. marwa.said@gmail.com Ronak S. Ahmed Department of Dermatology, Teaching Center for Treating Skin Diseases, Sulaimani Directorate of Health, Sulaymaniyah, Kurdistan, Iraq. dr-ronaksa@hotmail.com Lana R. A. Pshtiwan Department of Radiology, Shorsh Teaching Hospital, Sulaymaniyah, Kurdistan, Iraq. lana.pshtiwan@gmail.com Halkawt Omer Ali Smart Health Tower, Madam Mitterrand, Sulaymaniyah, Kurdistan, Iraq. halkawt.omer@gmail.com Yadgar A. Saeed Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. yadgar.saeed@gmail.com Abdulwahid M. Salih College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Kurdistan, Iraq. abdulwahid.salih@univsul.edu.iq 2023 10 15 Abstract Introduction This study aims to demonstrate the clinical presentation and treatment of epidermoid sinuses occurring in the intermammary region. They are formed by dome-shaped nodules resulting from burst pilosebaceous follicles. Methods The study is a retrospective multicenter case-series study. The cases were presented and treated for 12 years. It includes cases with a ruptured epidermoid cyst. The cases were managed through excision and primary closure of the lesion. Results The case series included 19 cases; 18 (95%) patients were female, and the age ranged between 15 to 30 years. All of the patients were obese. All the female cases had hyperpigmented patches in the intermammary region. All of them complained of discharge from the intermammary region for a prolonged period, ranging from 6 weeks to 2.5 years. Two cases (10.5%) developed recurrence and were managed by re-excision and primary closure. Conclusion The intermammary epidermoid cyst is a very rare form of the disease. The most effective management strategy is wide local excision with primary closure.