Barw Barw Medical Journal 2960-1959 2023 09 30 Pituitary Stalk Interruption Syndrome in a Child: A Rare Case Report with Literature Review 10.58742/dnfpv854 eng Honar O. Kareem Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. honar.kareem@gmail.com Bilal A. Mohammed Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. bilal.mohammed@gmail.com Karzan M. Hasan Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. karzan.hasan@gmail.com Shaho F. Ahmed Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. shahomedi87@gmail.com Fahmi H. Kakamad College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. fahmi.hussein@univsul.edu.iq Hawbash M. Rahim Department of Medical Laboratory Science, College of Health Sciences, University of Human Development, Kurdistan Region, Sulaimani, Iraq.. hawbash.mhamad96@gmail.com Berun A. Abdalla Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. berun.anwer95@gmail.com Shvan H. Mohammed Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq . shvanh80@gmail.com 2023 09 05 Introduction Pituitary stalk interruption syndrome is an exceedingly rare congenital abnormality affecting the pituitary gland that is still not fully understood. This study presents a 7-year-old child with the disease. Case presentation A 7-year-old male child was presented with short stature, school performance postponement, and an intellectual disability at a mild level. At 6.5 years of age, he had no facial features, was wearing eyeglasses, and had a weight and height of 20 kg (25th percentile) and 101 cm (3rd percentile), respectively. At the age of 7 years, his height was 117 cm (10th percentile) and his weight was 25 kg (50th percentile). Most laboratory tests were normal. However, insulin-like growth factor-1 and glucagon levels were low. A dynamic magnetic resonance imaging of the pituitary gland revealed an ectopic posterior pituitary lobe and the absence of a pituitary stalk. The patient was put on hormone replacement therapy (Norditropin pen) to control the growth hormone deficiency, and he was put under a close follow-up to monitor growth and panhypopituitarism. Conclusion Although hormone replacement therapy is associated with satisfactory outcomes in treating the syndrome, lifelong follow-up is indicated as new hormone deficiencies may arise later in life.