Barw Barw Medical Journal 2960-1959 2023 10 24 Comparative Analysis of ChatGPT and Human Decision-Making in Thyroid and Neck Swellings: A Case-Based Study 10.58742/bmj.v1i2.43 eng Zardasht Mahmud Ahamed Hospital of Treatment Victims Chemical Weapon in Halabja, Halabja, Kurdistan, Iraq. zardasht.ahmed@gmail.com Hardi Mohammed Dhahir Shahid Peshraw Hospital, Chamchamal, Sulaimani, Kurdistan, Iraq. . hardi.dhahir@gmail.com Miran Mawlood Mohammed Shar Hospital, Sulaimani, Kurdistan, Iraq.. miran.mohammed@gmail.com Rebaz Haji Ali Hiwa Cancer Hospital, Sulaimani Directorate of Health, Kurdistan, Iraq.. rebaz.ali12@gmail.com Shko H. Hassan Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. shko.hassan98@gmail.com Aso S. Muhialdeen Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. aso.muhialdeen@gmail.com Yadgar Abdulhameed Saeed Baxshin Hospital, Malik Mahmud Street, Sulaimani, Kurdistan, Iraq.. yadgar.saeed@gmail.com Mariwan L. Fatah College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. mariwan.fatah@univsul.edu.iq Aras J. Qaradakhy Department of Radiology, Shorsh Teaching Hospital, Sulaimani, Kurdistan, Iraq.. aras.qaradakhy@gmail.com Rawa M. Ali Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. rawa.ali@gmail.com Shaho F. Ahmed Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. shahomedi87@gmail.com Ari M. Abdullah Sulaimani Teaching Hospital, Sulaimani, Kurdistan, Iraq. ariabdullah1978@gmail.com Hawbash M. Rahim Department of Medical Laboratory Science, College of Health Sciences, University of Human Development, Kurdistan Region, Sulaimani, Iraq.. hawbash.mhamad96@gmail.com Berun A. Abdalla Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq . berun.anwer95@gmail.com Abdulwahid M. Salih College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. abdulwahd.salih@gmail.com Shvan H. Mohammed Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq . shvanh80@gmail.com Fahmi H. kakamad College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. fahmi.hussein@univsul.edu.iq 2023 10 03 Abstract Introduction This study aimed to evaluate the performance of Chat Generative Pre-Trained Transformer (ChatGPT), an AI-powered chatbot, in providing treatment recommendations for head and neck nodules. Methods Ten diverse cases were examined, including individuals with varying ages and conditions such as thyroid nodules and suspicious neck lesions. The decisions made by ChatGPT were compared to those of physicians. Data were collected from the Smart Health Tower on May 2, 2023. Results Analysis of the cases revealed that ChatGPT provided recommendations that aligned with physicians' decisions in seven cases. However, disparities were observed in three cases (N5, N8, N10). Discrepancies were influenced by factors such as nodule size, thyroid function, and the presence of associated symptoms. Conclusion The findings suggest that ChatGPT can assist healthcare professionals in formulating individualized diagnoses and treatment strategies for head and neck nodules. However, further research is needed to validate the performance of ChatGPT in larger patient populations and assess its long-term impact on patient outcomes.