Barw Barw Medical Journal 2960-1959 2023 06 10 The Role of G1/S Phase Cyclins in Colorectal Cancer: A Review 10.58742/bmj.v1i2.31 eng Hawbash M. Rahim Department of Medical Biology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey . hawbash.mhamad96@gmail.com Omer Ates Department of Medical Biology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey . omer.ates@gmail.com Fahmi H. Kakamad College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. fahmi.hussein@univsul.edu.iq Marwan N. Hassan Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. marwan.nasih12@gmail.com Berun A. Abdalla Smart Health Tower, Scientific Affairs Department, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. berun.anwer95@gmail.com Hiwa O. Abdullah Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq. hiewaom96@gmail.com Shvan H. Mohammed Kscien Organization for Scientific Research (Middle East office), Hamid Str, Azadi Mall, Sulaimani, Kurdstan, Iraq. shvanh80@gmail.com Rawezh Q. Salih Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq. Rawezh.mohammed@univsul.edu.iq Fakher Abdullah Kscien Organization for Scientific Research (Europe office), Verboomstraat 175b, 3082 jj Rotterdam, Netherlands. fakherabdullah1976@gmail.com 2023 04 25 Abstarct Colorectal cancer is a highly prevalent cancer with a high mortality rate. Although the colorectal carcinogenesis mechanism is not fully understood yet, it has been proven that most cancers result from the accumulation of genetic mutations, mostly in the genes responsible for cell cycle regulation, leading to uncontrolled and excessive cell growth. Hence, cyclins may have a significant role in cancer development and progression. Although many studies have been carried out on the expression of these cyclin proteins to indicate their role in colorectal cancer development and their correlation with patient outcome, the currently available data is quite controversial; thus, no certain conclusions can be made. This review article summarizes current knowledge regarding the role of G1/S cyclins, such as cyclin D, E, and A, in colorectal cancer and discusses their potential as prognostic biomarkers and therapeutic targets. Hence, it may provide the groundwork for future research.