Barw Barw Medical Journal 2960-1959 3 2 2025 03 20 Gastric Pyloric Schwannoma: A Case Report and Review of the Literature 10.58742/bmj.v3i2.168 eng Rebaz M. Ali Department of Oncology, Hiwa Hospital, Sulaymaniyah, Iraq. rebaz.ali12@gmail.com Shkar O. Arif Department of Radiotherapy, Zhianawa Cancer Center, Qirga, Sulaymaniyah, Iraq. shkar.arif@gmail.com Rezhen J. Rashid Department of Radiology, Hiwa Hospital, Sulaymaniyah, Iraq. rezheen.rashid@gmail.com Rawa M. Ali Hospital for Treatment of Victims of Chemical Weapons, Halabja, Iraq. rawa.ali@gmail.com Abubakar Ibrahim Department of Obstetrics and Gynaecology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. abubakr.ibrahim@gmail.com Dana T. Gharib Gastroenterology and Hepatology Teaching Hospital, Sulaymaniyah, Iraq. dana.gharib@gmail.com Marwan A. Ghafoor School of Health Sciences, Health Campus, Universiti Sains Malaysia Kubang Kerian, Kelantan, Malaysia. marwan.ghafoor@gmail.com Afolabi Hafeez Abiola Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian Kelantan, Malaysia. afolabi.abiola@gmail.com Bamiro Akeem Moradehun Anatomy Department, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia. bamiro@gmail.com Shano M. Ali Scientific Affairs Department, Smart Health Tower, Madam Mitterrand Street, Sulaymaniyah, Iraq. shano.ali@gmail.com Dear A. Ismaeil College of Medicine, University of Sulaimani, Madam Mitterrand Street, Sulaymaniyah, Iraq. deari.ismaeil@univsul.edu.iq Hoshman R. Asaad Gastroenterology and Hepatology Teaching Hospital, Sulaymaniyah, Iraq. hoshmand.asaad@gmail.com 2025 02 10 Abstract Introduction Schwannomas are slow-growing, subclinical neoplasms rarely found in the gastrointestinal tract. This study reports a schwannoma in the pyloric region of the stomach. Case presentation A 50-year-old female presented with a one-week history of epigastric pain, dark tarry stools, and nausea. Endoscopic examination and biopsy confirmed the diagnosis of gastric schwannoma. The patient underwent surgical resection of the tumor. Histopathological examination showed benign spindle cells with strong S100 positivity, confirming schwannoma. Post-operative follow-up included treatment for H. pylori infection and monitoring for recurrence or complications. No recurrence was reported after six months. Literature Review Gastric schwannoma is challenging to distinguish from other submucosal tumors preoperatively. Reviews of recent case reports indicate the importance of detailed imaging in diagnosis, and surgical resection remains the treatment of choice, with an excellent prognosis and low recurrence rates. Conclusion Schwannoma is rare in the stomach, especially in the pyloric region. Definitive diagnosis may require immunohistochemical analysis. Appropriate follow-up after treatment can be essential to identify emerging complications and ensure timely intervention.